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The commenter indicated that this conclusion was based on the limited weight gain or lack of weight gain found in animals given these steroids compared to control animals not exposed to the steroids. However, a more careful evaluation of the data suggests that this observation is inaccurate. Indeed, the body mass index for these animals treated with 10 or 20 μg/L of 17alpha-Estradiol was 10 kg/m 2 (range, 2-36 kg/m 2 ). The weight gain experienced by these animals compared to the controls was about 7 kg (range, 2.7-30.5 kg) at 3 months after injection. At 3 years after treatment, animals treated with 50 μg/L or 20 μg/L of 17alpha-Estradiol had no weight gain, no increase in body weight, and no alterations in the histology of any organs (see , for a complete description). Furthermore, at approximately 10 years of age, the animals receiving these steroids and the control animals receiving nonsteroidal anti-inflammatory drugs (NSAIDs) were indistinguishable in size, shape, and location of their internal organs (Fig. ). Open in a separate window Taken together, several reports have suggested that anabolic and androgenic steroids increase weight gain in nonanimal models of obesity. These results should prompt caution when these steroids are prescribed as therapy for obesity. In the context of this review, it is essential to recognize that these results in the nonobese are in fact "very" similar to those found in highly motivated individuals. In fact, the average lifetime dose of anabolic androgenic steroids used by these animals may be lower than the mean lifetime dose used by individuals with a normal body weight. Thus, one could reasonably assume that the animal's body weight might be stable throughout this period, which may or may not affect the outcome of this review. Pregnancy of Female C57BL/6 Mice After 16 weeks of treatment, there were no pregnancies among the animals given the high dose of 17alpha-Estradiol. However, there were nine pregnancies among the control animals given nonsteroidal anti-inflammatory drugs and no pregnancies amongst the animals receiving 100 mg/kg 18β-Estradiol, and there was one pregnancy among the animals treated with 100 mg/kg of 14β-Estradiol. At 30 days after treatment, the number of pregnancies in the control and the treated groups were equal (10/5 and 7/5, respectively). At the end of 30 weeks, the numbers of animals in the treatment and control groups were comparable (21/19). In the group of animals treated with 20 μg/L of 17α-Estrad Similar articles:
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